BIOmolecular Nanomachines with ever–Increasing Complexity and Size LABoratory
"Everything in biology is mechanical." – Julio Fernandez
The overarching research objective of the BioMAN Lab is to uncover the fundamental physical forces that govern how cells generate, detect, and respond to mechanical forces at the molecular level. We have developed a set of DNA nanotechnology, super-resolution microscopy, biophysics, protein engineering and molecular analytic tools that empower us to achieve our goals.
"What I cannot create, I do not understand." – Richard Feynman
Our lab is using DNA nanostructures to reconstruct mechanically-functional biomolecular systems while capturing their spatial and mechanical contexts.
These biologically, spatially, and mechanically-relevant reconstituted systems are amenable to mathematically-rigorous, physically-sound, and highly-predictive modeling.
The Mechanobiology of Malaria Parasite Invasion
The initial theme of our lab will focus on the mechanical interactions that power and guide malaria parasite invasion. Malaria, an infectious disease caused by deadly Plasmodium parasites, is a global health concern. In 2013, malaria was responsible for ~200 million cases and claimed >500,000 lives, which is equivalent to ~1 death per minute.
Low-Cost Single Molecule Nanoarray for Democratizing Digital Diagnostics
Finally, our lab will put this knowledge to work. From the biomedical translational standpoint, we will also develop lithography-free cm-scale DNA origami nanoarrays for high-throughput single-molecule biophysics and low-cost digital diagnostics that target minuscule concentrations of biomarkers.
RIZAL F HARIADI, ERIK WINFREE, AND BERNARD YURKE
"And so he looked at a tiny bubble
bursting on the surface of an infinite ocean.
Within it, molecules, their world torn asunder.
And in that vigor,
and in that endless churning,
the origin of life.
We followed him deep into this vision."
– Erik Winfree
RIZAL F HARIADI, RF SOMMESE, AS ADHIKARI, RE TAYLOR, S SUTTON, JA SPUDICH, ANAD S SIVARAMAKRISHNAN
YEE H TEE, TOM SHEMESH, VISALATCHI THIAGARAJAN, RIZAL F HARIADI, KAREN L ANDERSON, CHRISTOPHER PAGE, NIELS VOLKMANN, DORIT HANEIN, SIVARAJ SIVARAMAKRISHNAN, MICHAEL M KOZLOV, AND ALEXANDER D BERSHADSKY
Band of Heroes
These people (minus Rizal) are the real heroes of the lab.
(co-advised with Hao Yan)
ASU – Chemistry
ASU – BME
Swechchha "Sway" Pradhan
ASU – Biological Design
ASU – Physics
2020 Goldwater Scholar
Sritharini "Esha" Radhakrishnan
ASU – Biology & Math
B.Sc – Surya University
ASU – BME
ASU – Chemical Engineering
Honorary lab member
ASU – Physics & Math
Frequent Visitors & Collaborators
Boise State University
formerly at University of Michigan
MIT & Caltech
While we hate to say goodbye, our goal is to guide them toward achieving their dreams!
Rishabh M. Shetty (2017–2019): Now a postdoc @ MIT (PI: Ashwin Gopinath), co-advised by Paul Rothemund (PI @ Caltech).
Visiting postdocs, summer undergraduate researchers, postbacs
High school student
for Science, for humanity, for a better future
We celebrate everyone's birthday and our successes with papers, grants, and life events.