• background image
    background image
    background image
    background image
    background image
  • Our Recent Papers
    Innovation overload! ​​⚡

    Hydrodynamically–active oily ocean surface as a cradle for the emergence of life

    F Djutanta, R Kha , B Yurke, and RF Hariadi

    In preparation

     

    High-speed 3D DNA-PAINT and unsupervised clustering for unlocking 3D DNA origami cryptography

    GBM Wisna, D Sukhareva, J Zhao, D Satyabola, M Matthies, S Roy, P Šulc, H Yan, and RF Hariadi

    bioRχiv: https://doi.org/10.1101/2023.08.29.555281

     

    A simple surface modification to generate atomically-flat and hydrophobic substrates for gliding assays with protein motors

    I Tengganu, N Karerakattil, S Dey, D Kishnan, and RF Hariadi

    In revision

    Chemrxiv: https://doi.org/10.26434/chemrxiv-2021-d62p2-v3

     

    2023

     

    Viral attachment blocking chimera composed of DNA origami and nanobody inhibits Pseudorabies Virus infection in vitro

    S Pradhan, C Swanson, C Leff, I Tengganu, MH Bergemand, GBM Wisna, IB Hogue, and RF Hariadi

    ACS Nano 2023 Accepted

    bioRχiv link: https://www.biorxiv.org/content/10.1101/2023.02.13.528373v1

     

    Decoding the hydrodynamic properties of microscale helical propellers from Brownian fluctuations

    F Djutanta, P T Brown, B Nainggolan, A Coullomb, S Radhakrishnan, J Sentosa, B Yurke, RF Hariadi*, and DP Shepherd*

    PNAS 2023 120 (22) e2220033120 

    *Authors supervised equally

     

    Gradient-mixing LEGO robots for purifying DNA origami nanostructures of multiple components by rate-zonal centrifugation

    J Sentosa, F Djutanta, B Horne, D Showkeir, R Rezvani, C Leff, S Pradhan, and RF Hariadi

    PLOS ONE 2023 18(7): e0283134.

     

    2022

     

    DNA-templated programmable excitonic wires for micron-scale exciton transport

    X Zhou, H Liu, F Djutanta, D Satyabola, S Jiang, X Qi, L Yu, S Lin, RF Hariadi, Y Liu, NW Woodbury, H Yan

    Chem 2022 8 (9), 2442-2459

     

    The right shoe for the job

    D Gandavadi, and RF Hariadi

    Science 2022 375 (6585), 1089-1090

     

    Viral aggregation: The knowns and unknowns

    S Pradhan, A Varsani, C Leff, CJ Swanson, and RF Hariadi

    Viruses 2022 14 (2), 438

     

    2021

     

    Bench-top fabrication of single-molecule nanoarrays by DNA origami placement

    RM Shetty, SR Brady, PWK Rothemund, RF Hariadi*, and A Gopinath*

    ACS Nano 2021, 15, 7, 11441–11450

    * Authors supervised equally

     

    2019

     

    Autonomous dynamic control of DNA nanostructure self-assembly

    L Green, HKK Subramanian, V Mardanlou, J Kim, R F Hariadi, and E Franco,

    Nature Chemistry 2019, 11, 510–520

     

    A Bayesian nonparametric approach to single molecule FRET

    I Sgouralis, S Madaan, F Djutanta, R Kha , RF Hariadi, and S Pressé

    J. Phys Chem B 2019, 123(3), 675-688.

     

    2016

     

    Patterning protein complexes on DNA nanostructures using a GFP nanobody

    RF Sommese, RF Hariadi, K Kim, M Liu, MJ Tyska, and S Sivaramakrishnan

    Protein Science 2016 25 (11), 2089-2094

     

    Engineering circular gliding of actin filaments along myosin-patterned DNA nanotube rings to study long-term actin–myosin behaviors.

    RF Hariadi, AJ Appukutty, and S Sivaramakrishnan

    ACS Nano 2016 10 (9), 8281-8288

     

    A coarse-grained model of DNA nanotube population growth

    V Mardanlou, LN Green, HKK Subramanian, RF Hariadi, J Kim, and E Franco

    DNA Computing and Molecular Programming: 22nd International Conference 2016

     

    Before employment at ASU

     

    2015

     

    Determining hydrodynamic forces in bursting bubbles using DNA nanotube mechanics

    RF Hariadi, E Winfree, B Yurke

    PNAS 2015 112 (45), E6086-E6095

     

    Using protein dimers to maximize the protein hybridization efficiency with multisite DNA origami scaffolds

    V Verma, L Mallik, RF Hariadi, S Sivaramakrishnan, G Skiniotis, and AP Joglekar

    PLOS ONE 2015 10 (9), e0137125

     

    Mechanical coordination in motor ensembles revealed using engineered artificial myosin filaments

    RF Hariadi, RF Sommese, AS Adhikari, RE Taylor, S Sutton, JA Spudich, and S Sivaramakrishnan

    Nature Nanotechnology 2015 10 (8), 696–700

     

    Cellular chirality arising from the self-organization of the actin cytoskeleton

    YH Tee, T Shemesh, V Thiagarajan, RF Hariadi, KL Anderson, C Page, ...

    Nature Cell Biology 2015 17 (4), 445-457

     

    Tuning myosin-driven sorting on cellular actin networks

    RF Hariadi, RF Sommese, and S Sivaramakrishnan

    Elife 2015 4, e05472

     

    More papers 

    BAM! POW!

  • Our Science
    Innovation overload! ​​⚡

    Biomolecular Mechanics

    broken image

    "Everything in biology is mechanical." – Julio Fernandez

     

    The overarching research objective of the BIONICS LAB is to uncover the fundamental physical forces that govern how cells generate, detect, and respond to mechanical forces at the molecular level. We have developed a set of DNA nanotechnology, super-resolution microscopy, biophysics, protein engineering and molecular analytic tools that empower us to achieve our goals.

    Biomolecular Nanotechnology

    "What I cannot create, I do not understand." – Richard Feynman

     

    Our lab is using DNA nanostructures to reconstruct mechanically-functional biomolecular systems while capturing their spatial and mechanical contexts.

    These biologically, spatially, and mechanically-relevant reconstituted systems are amenable to mathematically-rigorous, physically-sound, and highly-predictive modeling.

    The Mechanobiology of Malaria Parasite Invasion

    broken image

    The initial theme of our lab will focus on the mechanical interactions that power and guide malaria parasite invasion. Malaria, an infectious disease caused by deadly Plasmodium parasites, is a global health concern. In 2013, malaria was responsible for ~200 million cases and claimed >500,000 lives, which is equivalent to ~1 death per minute.

    Low-Cost Single Molecule Nanoarray for Democratizing Digital Diagnostics

    broken image

    Finally, our lab will put this knowledge to work. From the biomedical translational standpoint, we will also develop lithography-free cm-scale DNA origami nanoarrays for high-throughput single-molecule biophysics and low-cost digital diagnostics that target minuscule concentrations of biomarkers.

    The origins of life

    broken image

    "All of us who study the origin of life find that the more we look into it, the more we feel it is too complex to have evolved anywhere." – Harold Urey

     

    The most fundamental principle of the living system could have been concealed within the secret recipe to initiate life itself. Our lab combines various branches of science from organic chemistry, fluid mechanics, into geophysics and astrophysics to develop and test a protocell model that emerged from hydrodynamic forces acting on oil slicks trapped by an ancient ocean gyre. The oil slicks are light and water-insoluble organic materials made out of micrometeorite kerogen.

  • Our family of Bionauts

    broken image

    Rizal F.
    Hariadi 🇮🇩

    Assistant Professor

    Ph.D. Caltech

    CV

    broken image

    Ranjan
    Sasmal 🇮🇳

    Postdoctoral scholar

    Ph.D. – Jawaharlal Nehru Centre for Advanced Scientific Research, India

    broken image

    Prathamesh Chopade 🇮🇳

    Postdoctoral scholar

    Ph.D. – Sungyukwan University

    broken image

    Gde Bimananda Mahardika Wisna 🇮🇩

    Graduate student

    ASU – Physics

    broken image

    Hari Gauli 🇳🇵

     

    Graduate student

    ASU – Physics

    broken image

    Youssef Hassan 🇺🇸

     

    Undergraduate Researcher

    ASU – Biochemistry

    broken image

    Sri Ujjwal Reddy Beereddy 🇮🇳

    Undergraduate Researcher

    ASU – Computer Science

    broken image

    Rayhan Rizqi 🇮🇩

     

    Undergraduate Researcher

    ASU – Computer Science

    broken image

    Aaron Sakai 🇺🇸

     

    Undergraduate Researcher

    ASU

    broken image

    Malikakhon Kuchkarova 🇺🇿

    Undergraduate Researcher

    ASU – Biochemistry

  • Collaborators

    broken image

    Xu Wang

    ASU

    broken image

    Po-Lin Chiu

    ASU

    broken image

    "Bernie" Yurke

    Boise State University

    broken image

    Jong Seto

    ASU

    broken image

    Hao Yan

    ASU

  • Get in touch!

     Email or drop us a note below

  • Where we are

    The Biodesign Institute A (BDA), Arizona State University